AN ANTIBIOTIC 24010 B-1

Isolation of an antibiotic, S-583-B, related to rhodomycin A and B.

Lactoquinomycin B, a Novel Antibiotic Takayoshi

Streptomyces tanashiensis IM8442T was found to produce lactoquinomycin B, a novel antibiotic, together with lactoquinomycin A. Lactoquinomycin B was purified, and the physico-chemical and biological characteristics were studied. Lactoquinomycin B, C24H27NO9, mp 149~152°C (dec), FD-MS m/z 473 (M+), is a basic substance, showing UV 2meOH (s) 239 (15,100), 287 (3,450) and 369 nm (5,300), and 1R vm...

Antibiotic Stewardship without an Antibiotic Stewardship Program?

To promote heightened vigilance concerning antibiotic agents in Canadian hospitals, Accreditation Canada has implemented antibiotic stewardship as a required organizational practice.1 Antibiotic stewardship is the process of ensuring that only necessary and appropriate antibiotic agents are used and that their use is appropriate for each individual patient. It involves optimizing all steps of a...

B - 1 Cell Development : Evidence for an Uncommitted Immunoglobulin ( Ig ) M 1 B Cell Precursor in B - 1 Cell Differentiation

Murine phosphatidyl choline (PtC)–specific B cells in normal mice belong exclusively to the B-1 subset. Analysis of anti-PtC (V H 12 and V H 12/V k 4) transgenic (Tg) mice indicates that exclusion from B-0 (also known as B-2) occurs after immunoglobulin gene rearrangement. This predicts that PtC-specific B-0 cells are generated, but subsequently eliminated by either apoptosis or differentiation...

تکامل و عملکرد سلول های B-1

سلول های B -1 درصد کوچکی از لنفوسیت های B را تشکیل می دهند، که در چندین بافت مختلف از جمله پریتوئن و حفره پلور ساکن هستند. از نظر عملکردی، سلول های B -1 به وسیله تولید اکثریت آنتی بادی سرمی از کلاس IgM که قبل از پاسخ ایمنی اکتسابی، باعث ایجاد محافظت در برابر پاتوژن ها می شود، در ایمنی ذاتی شرکت می کنند. سلول های B -1 از پیش سازهای جنینی و نوزادی تولید می شوند که با پیش سازهای مغز استخوان بالغین...